Lycopene for Prostate Cancer – Research Summary

BACKGROUND: Harvard researchers reported in a 2002 article in the Journal of the National Cancer Institute that eating tomato products on a regular basis is associated with a reduced risk of prostate cancer. The research included more than 47,000 participants. Researchers then continued to follow the men for several more years to learn more about the specific foods that seem to protect men from prostate cancer. That research was published this year — also in the Journal of the National Cancer Institute. The study reports men who ate tomato sauce at least twice a week were about 20-percent less likely to develop prostate cancer when compared to men who rarely ate it.
CURRENT RESEARCH: Moffitt Cancer Center in Tampa, Florida is conducting a study to look at the mechanism by which lycopene actually stops the promotion of prostate cancer cells. For the study, men with cancer who are having their prostate surgically removed are participating. Generally, the men wait six weeks after diagnosis before they have the surgery. During the six-week period, each participant is given one of three doses of lycopene or a placebo. Researchers will then compare the cancer cells from the pre-surgical biopsy and to those after surgery to compare the cell growth. So far, more than 50 patients have participated. The preliminary results from this study are expected by the summer of 2004.
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SUPPLEMENTS VS FOOD? Lycopene supplements are available on the market, but researchers say the supplements may not offer the same level of health protection. Experts point out that so far most studies have looked at intake of foods in the context of a whole diet. Therefore, including lycopene-rich foods is recommended over taking a supplement. LYCOPENE-RICH FOODS: The best way to include lycopene in your diet is to eat more processed tomato products. Research shows the body better absorbs lycopene when tomatoes are processed. While raw tomatoes have some lycopene, it takes more of them to make the processed foods, meaning there is more lycopene in each serving. Below is a list of foods and their lycopene content:
Lycopene Content in Foods (mg/100g)
Tomato Paste 42.2
Spaghetti Sauce 21.9
Chili Sauce 19.5
Tomato Ketchup 15.9
Tomato Juice 9.5
Pink Grapefruit 4.0
Raw Tomato 3.0

 

Armstrong Promotes Cancer Research

Associated Press

AUSTIN, Texas – With Lance Armstrong pushing for a record sixth consecutive Tour de France title this summer, his cancer research foundation is using the signature color of the world’s most grueling bicycle race for a new fund-raising campaign. The Lance Armstrong Foundation and Nike are promoting the sale of yellow wristbands engraved with the message, “Live Strong.”

“Yellow has taught me the true meaning of sacrifice. Yellow makes me suffer. Yellow is the reason I’m here,” Armstrong said. “Young people with cancer should be empowered to fight hard, dream big and live strong.”

The company will donate $1 million to the foundation, which hopes to raise an additional $5 million through wristband sales. Proceeds will go to the foundation for programs for young people with cancer. Foundation President Mitch Stoller said officials hope the wristbands will become as recognizable as the pink ribbons associated with breast cancer.

Armstrong overcame advanced testicular cancer that had spread to his lungs and brain. He went from having a 50 percent chance to live in 1996 to a string a five straight tour wins from 1999-2003, forever linking himself with the yellow jersey worn by the tour leader and champion.

 

Bush’s Trillion $ LIES About SS

WASHINGTON, Oct. 26 /PRNewswire/ — The Susan G. Komen Breast Cancer Foundation, credited as the nation’s leading catalyst in the fight against breast cancer, released today a non-partisan comparison of key health care proposals announced by Vice President Gore and Governor Bush in their quest for the Presidency.  The comparison is based on answers to a health care questionnaire designed by the Komen Foundation, to which both campaigns responded.  The Foundation hopes that the side-by-side analysis of the candidates’ varying proposals will assist voters in comparing and contrasting the approach each would take to important health care issues impacting women and families.

As a leader in the healthcare arena, the Susan G. Komen Breast Cancer Foundation has consistently promoted a broad range of issues impacting women and families.  The Komen Foundation, a bipartisan non-profit organization, works to educate women throughout the United States about the importance of these issues in their daily lives.

The Komen Foundation is an international organization with 114 domestic Affiliates in 45 states and the District of Columbia, as well as three Affiliates in Germany, Greece and Italy.  Since its inception, the Komen Foundation has raised more than $300 million to support breast cancer research, education, and screening and treatment programs.  These programs include cutting-edge basic, clinical and translational breast cancer research, and innovative outreach programs in local communities to assist the medically underserved.  The Susan G. Komen Breast Cancer Foundation is a nonpartisan charitable organization that does not endorse or oppose any candidate for public office

PROSTATE CANCER RESEARCH FUNDING

Mr. President, I would like to call the attention of my colleagues to a national health epidemic that kills 40,000 American men every year and strikes hundreds of thousands more each year–prostate cancer. I am concerned about this disease and its impact on American men, particularly its disproportionate impact on African-American men.
  For too long prostate cancer has been a silent killer. Too little has been known about it. Too little was said about it. Too little has been done about it. Fortunately, in recent years many prominent national figures like Senator Bob Dole, General Norman Schwarzkopf, Arnold Palmer, Sidney Poitier, Andy Grove, and Harry Belafonte have come forward to discuss their personal battles with prostate cancer. The admirable leadership of these men and others has helped educate the country about the importance of screening and early diagnosis of prostate cancer, and the need for all of us to do more to fight this disease.
  Mr. President, prostate cancer is the most commonly occurring non- skin cancer in the United States. In 1997, more than 200,000 men were diagnosed with prostate cancer and 41,800 died of the disease. Every three minutes a new case of prostate cancer is diagnosed and every 13 minutes someone dies from the disease. While it is often thought to be an older man’s disease, younger men are increasingly diagnosed with prostate cancer. In fact, about 20 percent of prostate cancers are now occurring in men between the ages of 40 and 60.
  Although prostate cancer accounts for approximately 20 percent of all new non-skin cancers, it receives less than four percent of federal cancer research funding. In 1996, approximately the same number of lives were lost due to prostate cancer breast cancer and AIDS. In 1997, however, while prostate cancer deaths continued to rise, deaths due to breast cancer and AIDS declined. Nevertheless, the federal commitment to prostate cancer research has not even kept pace with these other
priorities.
  Clearly, I am not advocating reduced funding for breast cancer or AIDS research programs. I have been one of the major champions of breast cancer and AIDS research funding. Rather, I use these comparisons to make the point that much more must be done to address the prostate cancer epidemic as well. How can we face the hundreds of thousands of men and their families who are daily affected by prostate cancer knowing, for instance, that more money was spent to make the movie Titanic–more than $200 million–than was spent in 1997 by the federal government for prostate cancer research–only $120 million?
  The possibility and the fear of developing prostate cancer are common to all men. One in five American men will develop prostate cancer during his lifetime. As frightening as that statistic may be for the general population, it is even more pointed in the African-American community. African-American men have a prostate cancer incidence more than 30 percent higher than for any other ethnic groups in this country and the highest in the world.
  The prostate cancer mortality rate for African-American men is more than twice that of white American men. Researchers do not yet know why this is true and do not yet have answers to these and the many other questions about prostate cancer. For example, it is not clear which prostate cancer patients will benefit from traditional treatments, like surgery or radiation. The economic status of many African-American men, and limited access to medical counseling further complicated treatment decisions.
  Those who are devoted to relieving the burden of prostate cancer in the African-American community, including scientists, health care providers, national organizations, community leaders, and survivors alike, are united in their desire to find answers to these questions. I am particularly pleased with the leadership of many national organizations in informing the country about the impact of prostate cancer in the African-American community. In November of last year, the American Cancer Society, the National Cancer Institute, and the Centers for Disease Control and Prevention sponsored A Leadership Council on Prostate Cancer in the African-American Community. In cooperation with the Intercultural Cancer Council, the National Black Leadership Initiative on Cancer, the National Prostate Cancer Coalition and the 100 Black Men of America, the Leadership Conference proposed a blueprint for action that aims to solve the problem of prostate cancer in the African-American community.
  These private organizations–and many others–are working very hard at the community and national levels to see that the prostate cancer epidemic is addressed. That a letter that 29 organizations representing the African-American community sent to Congress in May laying out a research funding agenda to attack this problem be printed in the Record.

Vitamin D Receptor Polymorphisms and Cancer Risk

PHILADELPHIA Subtle differences in the receptor for vitamin D reverse the anti-cancer action of the sunshine vitamin, increasing the risk of breast cancer in Caucasian women and prostate cancer in African-American men, according to two new studies. The results, in journals published by the American Association for Cancer Research, underscore how naturally-occurring variants of the same gene, called polymorphisms, can have implications for cancer initiation and progression.

For example, in the breast cancer study, British scientists at St. George¹s Hospital Medical School in London found that Caucasian women, who carried specific versions of the vitamin D receptor gene, or VDR, not only experienced increased risk for this cancer but may also be more prone to developing metastases.

Differences in the gene sequence for the vitamin D receptor are associated with breast cancer risk and may also be linked to disease progression said Kay Colston, Ph.D., the senior author of the study, published in the August 15 issue of the journal Clinical Cancer Research. Colston is a Reader in the Department of Cellular and Molecular Medicine at St. George¹s Hospital Medical School.

Among three known variable regions of the VDR gene considered by the research team, the bb and LL variants increased breast cancer risk by almost twofold. The F variant of the gene had no significant effect on breast cancer risk by itself, however when coupled with the LL genotype the risk of breast cancer was increased by a higher factor than the bb or LL genotypes alone. In addition, there was a higher proportion of women with this Œat risk genotype in a sub-group of patients who developed metastatic disease.

A second study, conducted independently, linked a similar change in the vitamin D receptor (VDR) with amplified risk of prostate cancer for African American men. That study appeared in the August issue of Cancer Epidemiology, Biomarkers & Prevention, a sister publication to Clinical Cancer Research.

Intriguingly, the F variant that increases the chance of developing breast cancer when associated with other VDR variants also contributes to increased risk and aggressiveness of prostate cancer in African-American men, according to the Cancer Epidemiology, Biomarkers & Prevention article. This study reported that men with two copies of the F variant almost doubled the risk for prostate cancer developing in African-Americans, but not Caucasians. Furthermore, the same men had twice the risk for developing high grade advanced prostate cancer, according to the research.

More African-American prostate cancer patients carried the homozygous FF variant of the vitamin D receptor than African American men who did not have prostate cancer, said Alice S. Whittemore, Ph.D., the senior author of the paper. Whittemore, who conducts cancer research in the department of Health Research and Policy, the Stanford University School of Medicine, led a multi-institutional team of cancer scientists from Stanford University, the University of Southern California, the University of Hawaii, the British Columbia Cancer Agency and the Northern California Cancer Center.

Neither the b nor L gene variants that altered risk in Caucasian women in the British study contributed to elevated risk for prostate cancer among men. Funding for the prostate cancer studies came from NIH grant CA67044. The UK breast cancer study was funded by Breast Cancer Campaign and the World Cancer Research Fund.

 

Postdoctoral Position in Signal Transduction and Cancer

Immediately available in Department of Pathology, Yale University School of Medicine. The applicant must have strong background in molecular biology or immunology or cancer biology. The commitment to basic science research is required.  The applicants with the potential to obtain a fellowship from NIH or other foundations are prefered.

Project will involve studies of signal transduction from cytokine receptors to transcription factor STAT and their possible roles in cancer development.

Background and our Research Interest:

A variety of protein ligands (such as hormones and cytokines) induce activation of protein tyrosine kinases (PTK) and affect gene expression.   Our laboratory working on a recently established signaling pathway involving direct activation of cytoplasmic transcription factors by tyrosine kinases. A direct signaling model of signal transduction has been proposed (Fu, 1992). In this model, the transcription factors (termed STAT) are directly activated by a membrane receptor-associated tyrosine kinase(s) through their   SH2 (Src homology region 2) domains. These activated transcription factors then translocate to the nucleus to join a nuclear protein to form an active transcriptional complex, inducing expression of specific functional proteins.  Most recently, studies from our lab and other laboratories have also demonstrated that Interferons, EGF, PDGF, CSF-1, IL-2, IL-3, IL-4, IL-5, IL-6, and IL-10 etc., all use this direct pathway to control nuclear transcriptional events (reviewed in Darnell et al., 1994). A fundamental question in cancer research is whether and how these signaling pathways are involved abnormal cell growth and transformation of normal cells.  Our current research is aiming to expand our understanding of the signal transduction of cytokines, especially the functions of STAT to the field of cancer immunology which includes STAT function in  cancer development  and in the general cellular immune responses.

 

BREAST CANCER RESEARCH — Buy Postage Stamps!!

As you may be aware, the US Postal Service recently released its new “Fund the Cure” stamp to help fund breast cancer research. The stamp was designed by Ethel Kessler of Bethesda, Maryland.  It is important that we take a stand against this disease that kills and maims so many of our mothers, sisters, and friends.

Instead of the normal $.33 for a stamp, this one costs $.40.  The additional $.07 will go to breast cancer research.  A “normal” book costs $6.60.  This one is only $8.00. It takes a few minutes in line at the Post Office and means so much.  If all stamps are sold, it will raise an additional $16,000,000 for this vital research. Many of us know women and their families whose lives are turned upside-down by breast cancer.  It takes so little to do so much in this drive.

While I have no objection to the issuance of semi-postal stamps to fund breast cancer research, I think that is is a self-deception.  The cure, if that is the correct term, is most likely to come from fundamental biological research pursued by biologists that are not quite so goal oriented to meet their sponsors’ desires.

During Nixon’s presidency, a “war” on cancer was started.  More than 20 years later the biggest steps to fight cancer have come from mainline biological research into subjects like genetics, angiogenesis, drug action, etc.  While the money spent was not wasted, it was not used efficiently.  The goal oriented research tries to tackle problems for which the science is not available.  It does sound good, however, to the desperate suffering from the disease.  In a sense, the science for a cure is not here yet.

It should be obvious to this group that arthritis has not been cured although fundamental knowledge has greatly increased.  The result has been better treatments.  Realize however, that study of autoimmune disease and immunity in general, for example, is what will pay dividends for BOTH arthritis and breast cancer therapy.

We also see another useless war in action.  The war on drugs.  It too is a means to divert resources into the pockets of special interests while doing little to solve our nation’s drug problems. I just had to get on my soap box.  It irks me to see people following panaceas that will only prove to be a disappointment.  The main advantage, not to be underated, is that it makes people feel emotionally better.

 

 

Todays Cancer Research a fraud !

If you did not see her show, you missed one of the best investigative reports into the mishandling of cancer research.  It appears most all is directed to the benefit of pharamacueticals…surprised?  Alot of power in the pursuit of selfish profit. In one scence Wendy Mesley confronts the head of the Cancer Society, and asks why all the other ‘chemical’ contaminants in our environment including pharmaceutical drugs, especially ‘the pill’ are not mentioned as risk factors in the cancer brochures.  The CEO from the Cancer Society has no answers, she just stumbles.

Well we move to a scene in France where the Drug companies are flogging their new drugs, wearing thousand dollar suits and gleaming since business was never so good and no one is really pursuing prevention as the cure. Sad, sad state where we have almost created a cult surrounding Cancer. Wendy Mesley should be given an award for daring to ask the question that no one else would!

There is another culprit involving cancer as well; COW MILK. Dairy products contain a hormone that is precisely identical in cows and humans. It is IGF-1 (insulin growth type factor 1)

The hormones and proteins of dairy products survive digestion in part due to the huge calcium load that buffers stomach ph from 2.5 to 6.5 and the encapsulation of the proteins and hormones by shattered fats due to homogenization. All the dairy hormones and proteins that become systemic are attacked by the human immune system, except for IGF-1 which is recognized as a ‘friend’. Ever wonder why your kids are always sick? Their immune system is so busy fighting cow proteins/hormones it can’t deal with other invaders.

Growth parameters are determined by genetic code. As these parameters are met, hormone levels drop. Introducing bio-active hormones can inititiate cell proliferation of random cancer cells. EVERY human by age FORTY has cancer cells regardless of lifestyle or diet. Cancer research and dairy are both mega-business and neither wants the other to dissappear. They work so well together but to no one’s good and only to their mutual profit. Dairy causes cancer and gives researchers bigger budgets as cancer incidence rises. Cancer researchers in spite of the fact that they KNOW IGF-1 causes cancer cell proliferation and KNOW the ONLY source of IGF-1 other than the body is cow milk look the other way and pretend they don’t know.

Don’t wait for a magic pill to be developed. As long as you are fueling your cancer cells with IGF-1 there ain’t NEVER gonna be a cure. Prevention is the cure and prevention means NOTMILK.

 

Run for breast cancer research

I am not sure if you have or haven’t heard about this.  Next summer there will be a cross-Canada run that will be in the fund-rasing spirit for fighting breast cancer.  Janet Blades proposed thata similar venture be taken in the US as well, at the same time as the Canada run.  I responded, but alas I am inundated with school and cannot be of any use it seems.  So I will pass the word on, and any brave souls wishing to take up this cause may do so.  Please email me or Janet (I don’t think she’ll mind – if she does blame me) about any questions, but Janet’s the one to really turn to for answers.

I imported my proposal that I sent to the Canadian Cancer Society to the E-Mail, however, it’s tabs are out of whack, but you can get the idea. Try contacting a breast cancer research place, or the American Cancer Society or whoever, with a proposal of your own. Basically our accommodations are with the van (motor home thing) and food I will cover as I have to eat anyway!

There is a lot of work to be done, including trying to find sponsorship for the event, believe me, this is difficult.  However, you have a lot going for you.  You are in University; therefore you have a lot of people you can approach for help.  Try to form a committee as no-one can do it all alone. Decide on a route, find State Coordinators, who will in turn find county coords, who will in turn find runners, you hope.

There has been some interest through the rec.running.  If you decide that you can do this, post it.  If you decide that you’d love to help somebody else coordinate it, post that too, you never know, someone may want to do it but is scared of all of the responsibility/time etc. it would take.  Team work is the best thing to go for.  Because you’re in university, you could contact Universities in each state that you plan on going through for help.

See what you want to do before you go ahead it’s a big undertaking, but would look fantastic on a resume!!!! If you post your interest in the rec.running, you not only get potential coordinators, you get folks who want to run for a full day, I even got a guy who wants to be the sole runner for the whole event.  This is nice, but it defeats the purpose of reaching out to people, uniting the country in a common goal, spreading the word on breast cancer.

 

Raising Money for Breast Cancer Research

SACRAMENTO, CA —As a skilled and successful surgeon, Dr. Ernie Bodai has used his medical expertise to teach, invent surgical tools, start a business, and lecture. However, in January, he decided to work for “pennies” in very different realms…social activism and political lobbying. A thousand breast cancer operations has convinced Bodai, Chief of Surgery, at Kaiser Permanente, Sacramento, CA, that much larger- scale research is needed.  ”We just haven’t progressed in the diagnosis and treatment of breast cancer,” Bodai exclaims.

The Cure Breast Cancer (CBC) campaign would raise money in an innovative way.  Bodai is lobbying the Postal Service and Congress to issue a voluntary 33 cent postage stamp. If purchased, the extra penny would go to breast cancer research at the National Institutes of Health (This is not the recently issued Breast Cancer Awareness Stamp which does not raise any additional funds for cancer research.).  Dr. Bodai said, “60 billion dollars of 32 cent stamps are issued annually. If half of them were 33 cent stamps, that could raise as much as 300 million dollars.”

Although this goal hasn’t been achieved yet, Bodai is confident because of early successes. His compassion, civic mindedness, and talent have already impressed Congress.  In just nine months, Bodai and his volunteers have promoted and lobbied all the way to getting the breast cancer postage stamp introduced into both Houses of Congress, with ninety Representatives and four Senators on the bandwagon thus far.

Bodai works tirelessly for public support. With the help of supporters such as Mercy Davidchik, a breast cancer survivor, the surgeon conducts a “grass roots” campaign to get signatures on petitions to Congressional leaders and endorsements from all types of local, state, and national organizations.

“We have obtained many letters from city and county officials to Congress, and we just received the endorsement of the California State Senate,” said Davidchik, a former patient of Dr. Bodai.  Currently, we are conducting a nationwide letter writing campaign to get support and publicity from large health-related and  civic groups,” she added. National organizations already supporting the idea include the American Cancer Society and American Medical Association.

Opponents have raised concerns about costs of administering such a stamp, but Dr. Bodai’s plan calls for corporate donations from companies profiting from this disease to help defray the costs of designing, printing, and publicizing the stamp.The Postal Service, with its new computerized stamp accounting system, would issue the stamps and the extra funds would be transferred directly to the National Institutes of Health.”We want to prove that you still can get something for a penny,” said Davidchik. “This could raise hundreds of millions of dollars without any significant financial burden on individual citizens.”

While CBCtm has gathered much support, further help in the U.S. Congress is needed. Volunteers across the country need to circulate petitions or write individual letters to their U.S.