US-CA, An Associate Scientist in Cell Biology, Cancer Research

COMPANY
Well-equipped U.S. research headquarters of international drug discovery company. Attractive campus. Excellent resources. High caliber of science. Company is committed to cutting edge research. Provides cutting-edge tools and support. Highly collaborative environment.

DESCRIPTION
Cell biology associate scientist for a cancer research group heavily focused on breast cancer. Apply 3 to 5 years of relevant experience ideally acquired within an industrial biotech environment.

RESPONSIBILITIES
Within a cell biology department, support cancer research genomics program focused on breast cancer. Apply knowledge in cell biology, cell based assays, cell-cell and cell-matrix signaling mechanisms, and antibody experience. Develop, optimize and perform cell-based assays to evaluate novel-gene therapeutic candidates. Validate novel protein drug targets utilizing strategies such as neutralizing antibodies and anti-sense oligonucleotide-based gene knock-outs. Another validation method used will be transfections of wild-type and dominant negative protein.

LOCATION
San Francisco Bay Area.
QUALIFICATIONS
BS or MS in cell biology with 3 to 5 years of pertinent experience, ideally within an industrial biotech setting. Broad knowledge of cell biology. Cell based assay experience (ex: proliferation, apoptosis, migrations and/or invasion assays). Experience working with cancer cell lines. The ability to manipulate a cell is important. Two crucial areas of technical knowledge are: 1.) Mammalian cell transfection and 2.) Delivering antisense oligonucleotides. Ideally we are seeking experience in the culture and transfection of primary and established human cell lines. Strong interpersonal and problem solving skills also important..

DESIRED (Not Mandatory)
Possible growth factor experience. Extracellular matrix interaction. Familiarity with: DNA expression vectors. Antisense olignucleotides. Immuno-cytochemistry and antibody characterization. Molecular biology techniques: such as cDNA cloning, DNA and RNA isolation. Northern and Western blot analysis.

COMPENSATION
Competitive salary and benefits.

 

Postage Stamp to Raise Money for Cancer Research

LOS ANGELES- the Postal Service unveiled the design of the Breast Cancer Research “Semipostal” Stamp, here, at the Revlon Run and Walk for Women on May 9th. A nationwide issuance of this  self-adhesive stamp begins in early August.

As a 40 cent “semipostal,” the Breast Cancer Research stamp will be deemed valid for postage at the prevailing First Class Rate, currently 32 cents, with the extra 8 cents going to fund medical research at the National Institutes of Health (70 percent) and Department of Defense (30 percent).

The background of the vertically formatted stamp design features blue,yellow, orange, and green washes of watercolor.  Along the top are the words, “breast cancer” in capital letters.  A black ink drawing of a female figure is the main element, while the phrases “fund the fight” and “find a cure” appear in capital letters flowing left to right into a clockwise, circular pattern.

The stamp was designed by Ethel Kessler, a breast cancer survivor, of Bethesda, MD, and illustrated by Whitney Sherman of Baltimore, MD. This is the first time in history that the U.S. Postal Service has issued a “semipostal” stamp.  It took an act of Congress after “grass roots” campaigning by several groups led by Dr. Ernie Bodai of Sacramento, CA, to get this unique postage stamp issued.

Among the thousands at the unveiling ceremony, was Mercy Davidchik of Yuba City, CA, who was one of the most active volunteer workers in raising public support and promoting legislation to issue the Breast Cancer Research Stamp.   It is hoped that through purchase of these stamps, millions of dollars will be raised for breast cancer research, which  is considered the most commonly diagnosed cancer among all women in the U.S.

 

Breast Cancer Research Semi-postal Stamps

Breast Cancer Research Semi-postal Stamps are subject to special limitations and conditions:
    a. Breast Cancer Research Semi-postal Stamps provide a means for customers to make contributions toward breast cancer research. Breast Cancer Research Semi-postal Stamps are offered for sale for a limited time as provided under 39 U.S.C. 414.
    b. The price of the Breast Cancer Research Semi-postal Stamp is 40 cents. The postage value of the Breast Cancer Research Semi-postal Stamp is the First-Class Mail Non automation Single-Piece first-ounce letter rate in R100.1.2 that is in effect at the time of purchase. The difference between the purchase price and the First-Class Mail Non automation Single-Piece first-ounce letter rate in effect at the time of purchase constitutes a contribution to breast cancer research, and cannot be used to pay postage. Additional postage must be affixed to pieces weighing in excess of one ounce, pieces subject to the nonstandard surcharge, or pieces for which special services have been elected. The postage value of Breast Cancer Research Semi-postal Stamps is fixed according to the First-Class Mail Non automation Single-Piece first-ounce letter rate in effect at the time of purchase; the postage value of Breast Cancer Research Semi-postal Stamps purchased before any subsequent change in the First-Class Mail Non automation Single-Piece first-ounce letter rate is unaffected by any subsequent change in that rate.
    c. Contributions to breast cancer research made through purchase of Breast Cancer Research stamps are not refundable. The postage value of Breast Cancer Research stamps for purposes of exchange or conversion under P014 is determined by the First-Class Mail Non automation Single-
Piece rate in effect at the time of purchase

 

Lycopene for Prostate Cancer – Research Summary

BACKGROUND: Harvard researchers reported in a 2002 article in the Journal of the National Cancer Institute that eating tomato products on a regular basis is associated with a reduced risk of prostate cancer. The research included more than 47,000 participants. Researchers then continued to follow the men for several more years to learn more about the specific foods that seem to protect men from prostate cancer. That research was published this year — also in the Journal of the National Cancer Institute. The study reports men who ate tomato sauce at least twice a week were about 20-percent less likely to develop prostate cancer when compared to men who rarely ate it.
CURRENT RESEARCH: Moffitt Cancer Center in Tampa, Florida is conducting a study to look at the mechanism by which lycopene actually stops the promotion of prostate cancer cells. For the study, men with cancer who are having their prostate surgically removed are participating. Generally, the men wait six weeks after diagnosis before they have the surgery. During the six-week period, each participant is given one of three doses of lycopene or a placebo. Researchers will then compare the cancer cells from the pre-surgical biopsy and to those after surgery to compare the cell growth. So far, more than 50 patients have participated. The preliminary results from this study are expected by the summer of 2004.
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SUPPLEMENTS VS FOOD? Lycopene supplements are available on the market, but researchers say the supplements may not offer the same level of health protection. Experts point out that so far most studies have looked at intake of foods in the context of a whole diet. Therefore, including lycopene-rich foods is recommended over taking a supplement. LYCOPENE-RICH FOODS: The best way to include lycopene in your diet is to eat more processed tomato products. Research shows the body better absorbs lycopene when tomatoes are processed. While raw tomatoes have some lycopene, it takes more of them to make the processed foods, meaning there is more lycopene in each serving. Below is a list of foods and their lycopene content:
Lycopene Content in Foods (mg/100g)
Tomato Paste 42.2
Spaghetti Sauce 21.9
Chili Sauce 19.5
Tomato Ketchup 15.9
Tomato Juice 9.5
Pink Grapefruit 4.0
Raw Tomato 3.0

 

Armstrong Promotes Cancer Research

Associated Press

AUSTIN, Texas – With Lance Armstrong pushing for a record sixth consecutive Tour de France title this summer, his cancer research foundation is using the signature color of the world’s most grueling bicycle race for a new fund-raising campaign. The Lance Armstrong Foundation and Nike are promoting the sale of yellow wristbands engraved with the message, “Live Strong.”

“Yellow has taught me the true meaning of sacrifice. Yellow makes me suffer. Yellow is the reason I’m here,” Armstrong said. “Young people with cancer should be empowered to fight hard, dream big and live strong.”

The company will donate $1 million to the foundation, which hopes to raise an additional $5 million through wristband sales. Proceeds will go to the foundation for programs for young people with cancer. Foundation President Mitch Stoller said officials hope the wristbands will become as recognizable as the pink ribbons associated with breast cancer.

Armstrong overcame advanced testicular cancer that had spread to his lungs and brain. He went from having a 50 percent chance to live in 1996 to a string a five straight tour wins from 1999-2003, forever linking himself with the yellow jersey worn by the tour leader and champion.

 

Bush’s Trillion $ LIES About SS

WASHINGTON, Oct. 26 /PRNewswire/ — The Susan G. Komen Breast Cancer Foundation, credited as the nation’s leading catalyst in the fight against breast cancer, released today a non-partisan comparison of key health care proposals announced by Vice President Gore and Governor Bush in their quest for the Presidency.  The comparison is based on answers to a health care questionnaire designed by the Komen Foundation, to which both campaigns responded.  The Foundation hopes that the side-by-side analysis of the candidates’ varying proposals will assist voters in comparing and contrasting the approach each would take to important health care issues impacting women and families.

As a leader in the healthcare arena, the Susan G. Komen Breast Cancer Foundation has consistently promoted a broad range of issues impacting women and families.  The Komen Foundation, a bipartisan non-profit organization, works to educate women throughout the United States about the importance of these issues in their daily lives.

The Komen Foundation is an international organization with 114 domestic Affiliates in 45 states and the District of Columbia, as well as three Affiliates in Germany, Greece and Italy.  Since its inception, the Komen Foundation has raised more than $300 million to support breast cancer research, education, and screening and treatment programs.  These programs include cutting-edge basic, clinical and translational breast cancer research, and innovative outreach programs in local communities to assist the medically underserved.  The Susan G. Komen Breast Cancer Foundation is a nonpartisan charitable organization that does not endorse or oppose any candidate for public office

PROSTATE CANCER RESEARCH FUNDING

Mr. President, I would like to call the attention of my colleagues to a national health epidemic that kills 40,000 American men every year and strikes hundreds of thousands more each year–prostate cancer. I am concerned about this disease and its impact on American men, particularly its disproportionate impact on African-American men.
  For too long prostate cancer has been a silent killer. Too little has been known about it. Too little was said about it. Too little has been done about it. Fortunately, in recent years many prominent national figures like Senator Bob Dole, General Norman Schwarzkopf, Arnold Palmer, Sidney Poitier, Andy Grove, and Harry Belafonte have come forward to discuss their personal battles with prostate cancer. The admirable leadership of these men and others has helped educate the country about the importance of screening and early diagnosis of prostate cancer, and the need for all of us to do more to fight this disease.
  Mr. President, prostate cancer is the most commonly occurring non- skin cancer in the United States. In 1997, more than 200,000 men were diagnosed with prostate cancer and 41,800 died of the disease. Every three minutes a new case of prostate cancer is diagnosed and every 13 minutes someone dies from the disease. While it is often thought to be an older man’s disease, younger men are increasingly diagnosed with prostate cancer. In fact, about 20 percent of prostate cancers are now occurring in men between the ages of 40 and 60.
  Although prostate cancer accounts for approximately 20 percent of all new non-skin cancers, it receives less than four percent of federal cancer research funding. In 1996, approximately the same number of lives were lost due to prostate cancer breast cancer and AIDS. In 1997, however, while prostate cancer deaths continued to rise, deaths due to breast cancer and AIDS declined. Nevertheless, the federal commitment to prostate cancer research has not even kept pace with these other
priorities.
  Clearly, I am not advocating reduced funding for breast cancer or AIDS research programs. I have been one of the major champions of breast cancer and AIDS research funding. Rather, I use these comparisons to make the point that much more must be done to address the prostate cancer epidemic as well. How can we face the hundreds of thousands of men and their families who are daily affected by prostate cancer knowing, for instance, that more money was spent to make the movie Titanic–more than $200 million–than was spent in 1997 by the federal government for prostate cancer research–only $120 million?
  The possibility and the fear of developing prostate cancer are common to all men. One in five American men will develop prostate cancer during his lifetime. As frightening as that statistic may be for the general population, it is even more pointed in the African-American community. African-American men have a prostate cancer incidence more than 30 percent higher than for any other ethnic groups in this country and the highest in the world.
  The prostate cancer mortality rate for African-American men is more than twice that of white American men. Researchers do not yet know why this is true and do not yet have answers to these and the many other questions about prostate cancer. For example, it is not clear which prostate cancer patients will benefit from traditional treatments, like surgery or radiation. The economic status of many African-American men, and limited access to medical counseling further complicated treatment decisions.
  Those who are devoted to relieving the burden of prostate cancer in the African-American community, including scientists, health care providers, national organizations, community leaders, and survivors alike, are united in their desire to find answers to these questions. I am particularly pleased with the leadership of many national organizations in informing the country about the impact of prostate cancer in the African-American community. In November of last year, the American Cancer Society, the National Cancer Institute, and the Centers for Disease Control and Prevention sponsored A Leadership Council on Prostate Cancer in the African-American Community. In cooperation with the Intercultural Cancer Council, the National Black Leadership Initiative on Cancer, the National Prostate Cancer Coalition and the 100 Black Men of America, the Leadership Conference proposed a blueprint for action that aims to solve the problem of prostate cancer in the African-American community.
  These private organizations–and many others–are working very hard at the community and national levels to see that the prostate cancer epidemic is addressed. That a letter that 29 organizations representing the African-American community sent to Congress in May laying out a research funding agenda to attack this problem be printed in the Record.

‘Green’ terrorists set back cancer research

What if the knowledge that scientists might have gained about the cancer-like tree disease referred to below could have led to a cure for human cancer?
As an environmentalist myself I know that the possibility that greater scientific knowledge of plants and their diseases may lead to breakthroughs in the treatment and even cures of many human and animal
diseases.

“This group is sick. They damaged a program that is for the good of everyone. We feel personally violated.” — Jud Isebrands, scientist at federal forestry research center near Rhinelander. Calling it “an attack against bio-engineering,” a group of radical environmentalists said it destroyed 500 research trees and spray-painted graffiti on vehicles at a federal forestry laboratory near Rhinelander, officials said Friday.

The Seattle-based North American Earth Liberation Front, an underground environmental activist organization, claimed responsibility for killing rare nursery stock worth $750,000 and vandalizing eight vehicles at a research station run by the U.S. Forestry Sciences Laboratory. Using saws and machetes to cut down the trees, and then trampling on them, the group short-circuited a 30-year project aimed at finding a cure for a cancer-like disease that attacks poplar trees, said Jud Isebrands, a scientist at the facility.

In the Thursday night attack, the group painted large green-and-black slogans on automobiles that warned: “ELF is watching the U.S. Forest Service.” The group also spread acid on windshields, Isebrands said. Damage to vehicles was estimated at $20,000, he said. The ELF, which has claimed responsibility for 13 attacks causing $31 million in damages over the last six years, opposes manipulating genetic matter in plants and animals, said Craig Rosebraugh, the group’s spokesman.

At least four separate anti-bio-engineering groups have carried out more than 30 attacks this year at facilities that included strawberry and sugar beet fields in California, cornfields in Maine and a grass field in Oregon. But researchers at the Rhinelander nursery had not used bio- engineering methods on any of the trees that were destroyed, said Isebrands, a member of a team working to find a cure for septoria canker, a disease that forms tumor-like swellings on poplar trees, causing millions of dollars in damage nationwide.

“This was not bio-technology,” Isebrands said. “All of our work was done using traditional plant-breeding techniques that have been around for years. We simply took a genetically superior tree and matched it with another tree. Then you just hope to get a better plant.” Besides poplars, the attackers destroyed young red oaks and other tree species.

“This group is sick,” Isebrands said. “They damaged a program that is for the good of everyone. We feel personally violated. We run this area like a public park. It’s open to everyone. We don’t want to put razor wire around here.” The attack set back the research project by 10 to 15 years, Isebrands said. About 10 members of the research team had been preparing stock that requires about 10 years for each generation to mature before scientists can move on to the next phase.

ELF has taken credit for six similar attacks this year, including a New Year’s Eve incident involving a suite of offices at the Michigan State University’s Agriculture Hall. “ELF is definitely stepping up its actions,” Rosebraugh said. Rosebraugh said he was not a member of the group, but he received information from members, who remained anonymous.

ELF members work in small cells, he said, and members do not know the identity of members in other cells. The Wisconsin attack probably identity of members in other cells. The Wisconsin attack probably was conducted by members from outside the state, he said. To avoid getting caught, members rarely conduct attacks in their home states, he said.

Vitamin D Receptor Polymorphisms and Cancer Risk

PHILADELPHIA Subtle differences in the receptor for vitamin D reverse the anti-cancer action of the sunshine vitamin, increasing the risk of breast cancer in Caucasian women and prostate cancer in African-American men, according to two new studies. The results, in journals published by the American Association for Cancer Research, underscore how naturally-occurring variants of the same gene, called polymorphisms, can have implications for cancer initiation and progression.

For example, in the breast cancer study, British scientists at St. George¹s Hospital Medical School in London found that Caucasian women, who carried specific versions of the vitamin D receptor gene, or VDR, not only experienced increased risk for this cancer but may also be more prone to developing metastases.

Differences in the gene sequence for the vitamin D receptor are associated with breast cancer risk and may also be linked to disease progression said Kay Colston, Ph.D., the senior author of the study, published in the August 15 issue of the journal Clinical Cancer Research. Colston is a Reader in the Department of Cellular and Molecular Medicine at St. George¹s Hospital Medical School.

Among three known variable regions of the VDR gene considered by the research team, the bb and LL variants increased breast cancer risk by almost twofold. The F variant of the gene had no significant effect on breast cancer risk by itself, however when coupled with the LL genotype the risk of breast cancer was increased by a higher factor than the bb or LL genotypes alone. In addition, there was a higher proportion of women with this Œat risk genotype in a sub-group of patients who developed metastatic disease.

A second study, conducted independently, linked a similar change in the vitamin D receptor (VDR) with amplified risk of prostate cancer for African American men. That study appeared in the August issue of Cancer Epidemiology, Biomarkers & Prevention, a sister publication to Clinical Cancer Research.

Intriguingly, the F variant that increases the chance of developing breast cancer when associated with other VDR variants also contributes to increased risk and aggressiveness of prostate cancer in African-American men, according to the Cancer Epidemiology, Biomarkers & Prevention article. This study reported that men with two copies of the F variant almost doubled the risk for prostate cancer developing in African-Americans, but not Caucasians. Furthermore, the same men had twice the risk for developing high grade advanced prostate cancer, according to the research.

More African-American prostate cancer patients carried the homozygous FF variant of the vitamin D receptor than African American men who did not have prostate cancer, said Alice S. Whittemore, Ph.D., the senior author of the paper. Whittemore, who conducts cancer research in the department of Health Research and Policy, the Stanford University School of Medicine, led a multi-institutional team of cancer scientists from Stanford University, the University of Southern California, the University of Hawaii, the British Columbia Cancer Agency and the Northern California Cancer Center.

Neither the b nor L gene variants that altered risk in Caucasian women in the British study contributed to elevated risk for prostate cancer among men. Funding for the prostate cancer studies came from NIH grant CA67044. The UK breast cancer study was funded by Breast Cancer Campaign and the World Cancer Research Fund.

 

BREAST CANCER RESEARCH — Buy Postage Stamps!!

As you may be aware, the US Postal Service recently released its new “Fund the Cure” stamp to help fund breast cancer research. The stamp was designed by Ethel Kessler of Bethesda, Maryland.  It is important that we take a stand against this disease that kills and maims so many of our mothers, sisters, and friends.

Instead of the normal $.33 for a stamp, this one costs $.40.  The additional $.07 will go to breast cancer research.  A “normal” book costs $6.60.  This one is only $8.00. It takes a few minutes in line at the Post Office and means so much.  If all stamps are sold, it will raise an additional $16,000,000 for this vital research. Many of us know women and their families whose lives are turned upside-down by breast cancer.  It takes so little to do so much in this drive.

While I have no objection to the issuance of semi-postal stamps to fund breast cancer research, I think that is is a self-deception.  The cure, if that is the correct term, is most likely to come from fundamental biological research pursued by biologists that are not quite so goal oriented to meet their sponsors’ desires.

During Nixon’s presidency, a “war” on cancer was started.  More than 20 years later the biggest steps to fight cancer have come from mainline biological research into subjects like genetics, angiogenesis, drug action, etc.  While the money spent was not wasted, it was not used efficiently.  The goal oriented research tries to tackle problems for which the science is not available.  It does sound good, however, to the desperate suffering from the disease.  In a sense, the science for a cure is not here yet.

It should be obvious to this group that arthritis has not been cured although fundamental knowledge has greatly increased.  The result has been better treatments.  Realize however, that study of autoimmune disease and immunity in general, for example, is what will pay dividends for BOTH arthritis and breast cancer therapy.

We also see another useless war in action.  The war on drugs.  It too is a means to divert resources into the pockets of special interests while doing little to solve our nation’s drug problems. I just had to get on my soap box.  It irks me to see people following panaceas that will only prove to be a disappointment.  The main advantage, not to be underated, is that it makes people feel emotionally better.