Viral Cancer Research — April 1961

Science Holds Out Hope of Anti-Cancer Vaccine

Atlantic City – The chance discovery of a tumor-suffering monkey in the village of Yaba near the Nigerian capital of Lagos, may possibly lead to the development of an anti-cancer vaccine, three Buffalo scientists reported today.    The work reported at the American Association for Cancer Research meeting here by Elmer T. Feltz, a thirty-three-year-old graduate student at Roswell Park, and his teachers Dr. Julian L. Ambrus, principal cancer research scientist, and Dr. James T. Grace, assistant director of the Institute lends support to the virus theory.

The three Buffalo researchers began their work two years ago after reading a report about the sick Nigerian monkey in the British magazine, “Nature.” Briefly, this is what they read: A group of British doctors in Nigeria found a monkey that had a tumor. They placed the monkey in an out-of-doors cage with several other monkeys — some native to Africa, others that had been imported from Asia. After a time, all of the monkeys developed tumors.

A piece of the original monkey’s tumor was sent to the British government’s National Research Council laboratories in London, where Dr. C. A. Andrews found that a large virus caused the tumor. The British, more interested in influenza research, reported their findings and did no work with the tumor.

The Roswell Park men sent for a piece of the tumor and repeated the work. At Buffalo, they found they could inoculate Asian monkeys with the virus and without exception, they would develop tumors. However, when they inoculated African monkeys, some developed tumors but others did not.    The reason for the differing reactions, Dr. Ambrus said, could lie in the fact that the virus is native to Africa and that African monkeys have developed varying degrees of immunity to it.

At Buffalo the researchers housed monkeys with tumors in cages with healthy monkeys. They could not reproduce the epidemic that occurred in the Yaba cage. This, Dr. Ambrus said, could mean that blood-sucking insects — such as mosquitoes — are necessary to carry the disease from one animal to
another.

After working with the animals, Dr. Grace injected the virus into five volunteer patients who were dying of already-contracted cancer. About five days after inoculation, each of the patients developed a tumor the size of a half-dollar at the point where the virus had been injected. Dr. Grace removed some of the tumors and, after examining them under a microscope, found they were similar to those in the
monkeys.

Dr. Ambrus said the tumors could not be described as cancer. He said they were in a “gray area” between malignant tumors (cancer) and benign tumors (which are not cancerous). However, he said the possibility exists that the same virus, in a more virulent form, causes a skin cancer called Karposi’s Disease, which is common in tropical Africa among humans and monkeys and is found in rare cases in the United States, and “children’s lymphoma,” which has been raging in epidemic proportions in a belt from Northern Nigeria to Northern Kenya. [Burkitt's Lymphoma?]

Doctors in one African hospital have reported 106 cases of the children’s disease in the last few months. That disease affects the jawbone and abdomen of children between three and eight years old and kills within four to six months.

 

Stamps for Cancer Research

We need those of you who are great at forwarding on info with your email network. Please read and pass on.  Peace and good health. It would be wonderful if 2000 were the year cure for breast  cancer was found!!!! This is one note I’ll gladly pass on. The notion that we could raise $16 million by buying a book of stamps is powerful! As you may be aware, the US Postal Service recently released its new “Fund the Cure” stamp to help fund breast cancer research. The stamp was designed by Ethel Kessler of Bethesda, Maryland. It is important that we take a stand against this disease that kills and maims so many of our mothers, sisters, and friends.
Instead of the normal $.33 for a stamp, this one costs $.40. The additional $.07 will go to breast cancer research. A “normal” book costs $6.60. This one is only $8.00. It takes a few minutes in line at the Post Office and means so much. If all stamps are sold, it will raise an additional $16,000,000 for this vital research.
Just as important as the money is our support. What a statement it would make if the stamp out-sold the lottery this week. What a statement it would make that we care. I urge each of you to do two things TODAY:
1.Go out and purchase some of these stamps.
2. E-mail your friends to do the same.
Many of us know women and their families whose lives are turned upside-down by breast cancer. It takes so little to  do so much in this drive.

INTRODUCTORY STATEMENT FOR THE MILLENNIUM CANCER RESEARCH ACT

Ms. PRYCE of Ohio. Mr. Speaker, I rise today, along with my colleague Congresswoman Lois Capps, to introduce the Millennium Cancer Research Act. This important legislation authorizes a five-year demonstration project designed to increase the flexibility, effectiveness and creativity of our nation’s cancer research program. It has been developed in collaboration with the National Cancer Institute (NCI) and my colleagues in the Senate, in an effort to encourage high impact, cutting-edge research that will lead to future progress in the fight against cancer.
Mr. Speaker, each year millions of Americans are touched by cancer, as they or someone they know is struck by this terrible disease. We have made enormous strides in the war against this most formidable of opponents, but we must do more to accelerate success. As scientific breakthroughs occur and innovations happen, our nation’s cancer laboratories must be able to build upon them and should not be hindered by red tape.
This legislation will allow for a restructuring of the National Cancer Institute that will help to rid its scientific laboratories of redundancy and inefficiencies that slow progress in our ongoing battle against cancer. It will command accountability both to peers through mandatory reviews and to Congress through annual reporting requirements. This bill will provide the necessary flexibility to respond quickly to emerging research opportunities and to engage the brightest minds available while maintaining strict congressional oversight. It will allow NCI to streamline existing systems, maximize cost-effectiveness and more easily enter into strategic partnerships and collaborations in pursuit of a cure. In short, it puts in place an administrative structure that reflects the complex way in which research is conducted today.
Specifically, this legislation: Directs the NCI Director to establish a program to encourage high- impact, high-risk rapid response research; Provides NCI with authority similar to that given to the Defense Advanced Research Projects Agency (DARPA) to enter into multiparty agreements that recognize intellectual property rights as well as financial and in-kind contributions;
Allows NCI to create one simple and cost-effective personnel system to better recruit and manage priority research programs and initiatives; Updates the dollar level for grants that must be reviewed by the National Cancer Advisory Board to $300,000, in order to reflect inflation and the pace of science over the last 15 years; and   Requires the NCI Director to report annually to Congress on research initiatives advanced under this legislation and to the NIH Director on the potential benefits of expanding these activities to other Institutes.
Mr. Speaker, we are at a critical juncture in the war on cancer. By the year 2010, we face losing one-fourth of our citizens to this disease

Cancer Research / Animal Experimentation

According to the International Agency for Research in Cancer “…80-90 per cent of human cancer is determined environmentally and thus theoretically avoidable.” (5) Environmental causes of cancer include lifestyle factors such as smoking, a diet high in animal products and low in fresh fruit & vegetables, excessive exposure to sunlight, food additives, alcohol, workplace hazards, pollution, electromagnetic radiation, and even certain pharmaceutical drugs and medical procedures. But unfortunately, as expressed by medical historian Hans Ruesch, “Despite the general recognition that 85 per cent of all cancers is caused by environmental influences, less than 10 per cent of the (U.S.) National Cancer Institute budget is given to environmental causes. And despite the recognition that the majority of environmental causes are linked to nutrition, less than 1 per cent of the National Cancer Institute budget is devoted to nutrition studies. And even that small amount had to be forced on the Institute by a special amendment of the National Cancer Act in 1974.”

A large portion of money donated to cancer research by the public is spent on animal research which has, since its inception, been widely condemned as a waste of time and resources. For instance, consider the 1981 Congressional Testimony by Dr. Irwin Bross, former director of the Sloan-Kettering, the largest cancer research institute in the world, and then Director of Biostatistics at Roswell Park Memorial Institute for Cancer Research, Bufallo, NY: “The uselessness of most of the animal model studies is less well known. For example, the discovery of chemotherapeutic agents for the treatment of human cancer is widely-heralded as a triumph due to use of animal model systems. However, here again, these exaggerated claims are coming from or are endorsed by the same people who get the federal dollars for animal research. There is little, if any, factual evidence that would support these claims. Indeed, while conflicting animal results have often delayed and hampered advances in the war on cancer, they have never produced a single substantial advance either in the prevention or treatment of human cancer. For instance, practically all of the chemotherapeutic agents which are of value in the treatment of human cancer were found in a clinical context rather than in animal studies.”

In fact, many substances which cause cancer in humans are marketed as “safe” on the basis of animal tests. As expressed by Dr. Werner Hartinger of Germany, in regard to cancer-causing products of the pharmaceutical-petro-chemical industry, “Their constant consumption is legalised on the basis of misleading animal experiments which seduce the consumer into a false sense of security.”

 

Cancer Research Is a Cash Cow

I am not posting to dispute your statement, but to request the source. The rates for smoking-caused cancer are below the adult smoking rate. The latest figures for smoking-related disease I have been given by my GP (without attribution) are as follows: 10% of smokers develop an acute affliction – lung cancer, stroke, cardiovascular problems – and die rather early. 20% develop a chronic affliction – emphysema, vascular problems, etc. – which affect life style and reduce longevity. When pressed about the other 70% he grudgingly conceded: “No visible ill effects.” The oft-repeated slogan “Every cigarette is doing you harm” has no scientific backing. It would seem that tobacco is like many other substances: a serious risk to some, not a problem for others. With millions of smokers in the Western world, you can always find plenty of examples of those who live to a ripe old age but that doesn’t excuse the fact that, on average, smokers die younger than non-smokers.

Lung cancer is still one of the most common cancers, and compared with prostate, breast, and bowel cancer, has a much lower 5-year survival rate (15% for all types of lung cancers combined). 85% of lung cancer victims will have been smokers. “Lung cancer deaths have halved since 1965, mainly due to a reduction in the number of people who smoke. The findings come when, looking worldwide, deaths from tobacco related illnesses are increasing. ” “Researchers said that Britain should be held up as an example, although they stressed that smoking was still the biggest cause of premature death; half of all smokers would eventually be killed by their habit.” If you really don’t care about an extra 6.5 years tacked on at the end, by all means keep smoking. But for many of us, the idea of paying thousands of dollars a year simply to increase your chances of getting sick and dying sooner just doesn’t make a lot of sense.

Cancer research funding disparity. Why?

According to 1997 National Cancer Institute statistics, annual funding for breast cancer research is about $350 million. But annual funding for prostate cancer research is only about $60 million. Yet roughly equal numbers of men die annually from prostate cancer as women who die annually from breast cancer!

Our legislators see it that way because men prefer to tough it out in silence.  As someone who’s involved in both of these issues (my father died of prostate cancer, my wife had breast cancer) I’ve seen it firsthand. The women get together and STAY together on this topic; they support each other and rally around the issue and hold parties and marches, etc.

The prostate cancer organizations, by comparison, are tiny and can’t attract many men to events and rallies because guys don’t think that stuff is macho enough. Men don’t think it’s cool to support other men.  Based on last week’s news about a possible genetic basis for our (men’s) poorer social skills, maybe we can’t help it and we’re doomed to always be divisive and fractious.

 

64FR10950 Use and Determination of Postage Value of Breast Cancer Research Semi-postal Stamp

On July 16, 1998, the Postal Service published in the Federal Register a final rule (61 FR 38309) that established the standards in the Domestic Mail Manual (DMM) governing the use and determination of postage value of the Breast Cancer Research Semi-postal Stamp. The final rule took effect on July 29,
1998, the first date on which the Breast Cancer Research Semi-postal Stamp was made available for sale to the public in accordance with the Stamp Out Breast Cancer Act, Pub. L. 105-41, 111 Stat. 1119 (1997). The Stamp Out Breast Cancer Act provides that the Postal Service make a Breast Cancer Research Semi-postal Stamp available for sale to the public no later than August 13, 1998.
Although the Postal Service published the DMM standards pertaining to the Breast Cancer Research Semi-postal Stamp as a final rule, the Postal Service solicited public comment on the DMM standards implementing the Stamp Out Breast Cancer Act. The Postal Service received three comments, which are addressed below. The Postal Service has made minor changes to DMM standards pertaining to the exchange value of Breast Cancer Research Semi-postal Stamps. These revisions were effective January 10, 1999.
One concern raised by two commenters relates to the stamp’s postage value. In particular, the commenters noted that the postage value of the stamp will be determined by the First-Class Mail single-piece first-ounce rate in effect at the time of purchase, in lieu of the First-Class Mail single-piece first-ounce rate effective at the time of usage. The commenters expressed concern that this measure may be confusing for customers, given that the Breast Cancer Research Semi- postal Stamp does not bear a numerical denomination.
The Postal Service is sensitive to the commenters’ concerns; however, these standards are necessary to protect postal revenues. The Postal Service determines the amount of money available for breast cancer research based upon the First-Class Mail single-piece rate in effect at the time of purchase.
One commenter suggested that the Postal Service should issue semi- postal stamps bearing a numerical value equivalent to the First-Class Mail single-piece rate in effect at the time of purchase. The Postal Service appreciates this suggestion. In this case, however, the interests of administrative and operational simplicity are served by the absence of a numerical value on the stamp. It would have been difficult to adopt the commenter’s suggestion in this case, because the Postal Service could not predict the quantity of stamps that should be printed at each rate, given that, at the time the stamps had to be produced, no final decisions on rate changes, or their effective date, had been made.
Two commenters asked why customers will be required to present a dated receipt in order to receive exchanges for 33 cents postage. In response to these comments, the Postal Service will not require customers to present a receipt in order to receive exchanges for Breast Cancer Research Semi-postal Stamps. Breast Cancer Research Semi-postal Stamps will be exchanged at the postage value in effect at the time of exchange. The Postal Service does not expect to exchange many Breast Cancer Research Semi-postal Stamps, as self-adhesive stamps may only be exchanged under limited circumstances (see Domestic Mail Manual.
One commenter questions why the conversion and exchange value of the Breast Cancer Research Semi-postal Stamp is limited to its postage value. This standard is required because, by operation of the Stamp Out Breast Cancer Act, the revenue that the Postal Service receives from the differential (net of the stamp selling price and the postage value) must be transferred to the Department of Defense and the National Institutes of Health for the purpose of breast cancer research. Consequently, once the differential revenue is transferred, the Postal Service will not have access to the differential revenue paid for the purpose of funding postage exchanges and conversions.
One commenter questions whether the amount of the differential applies toward the $100 exchange limit in DMM P014.1.2. The exchange limit per transaction of $100 in P014.1.2 is not affected by the amount of the differential.
One commenter believes that the Stamp Out Breast Cancer Act should be interpreted so that the differential amount varies depending upon the First-Class Mail postage rate applicable to pieces weighing more than one ounce. This interpretation has no support in the legislative history, and would, moreover, require the adoption of sales and usage practices that would be completely unworkable. Under this interpretation, the Postal Service could not set a uniform price for the stamp; rather, the amount of differential would have to be separately determined whenever customers intended to use Breast Cancer Research Semi-postal Stamps to pay for postage above the first-ounce rate. This would also have the adverse effect of limiting the stamp’s marketability and utility, since the stamp’s price would have to be separately determined for each mailing transaction.
One commenter asked what postage value Breast Cancer Research Semi-postal Stamps would have when such stamps are used in multiples. Each Breast Cancer Research Semi-postal Stamp purchased before January 10, 1999, will have a postage value of $0.32, regardless of whether such stamps are used in multiples.
One commenter questioned whether the Breast Cancer Research Semi-postal Stamp could be used to pay postage for classes of mail other than First-Class Mail, or for international mail. Breast Cancer Research Semi-postal Stamps are considered no denominated stamps and may be used on domestic classes other than First-Class Mail to the extent

Buffy and Faith

However, cancer research on animals does not benefit humans. It’s done so researchers can pretend they’re making progress by publishing boring articles (they only want to be famous.) Do we need to know that a rat will get cancer if it’s fed a ton of saccharin? Or if dogs will die if they are forced to inhale smoke all day? I think not. The PCRM Guide to Cruelty-Free Giving lists 9 cancer charities that do not fund animal experiments so why not support one of them instead of a charity that will use your money to torture animals who are expendable thanks to your generous donation?

Excuse me, but do you people have any real idea how science works?  How do you think it was found that smoking causes cancer?  Should they have taken Maury Povich and forced him to puff all day?  Research is done on tissue that most closely resembles human when it is impractical or immoral to use humans. Massive doses are used in cancer research to shorten the time frame of the effect of the suspected carcinogen.  If a chemical is not a carcinogen then NO dosage will cause a neoplasm.  If a chemical is a carcinogen then larger doses will shorten the time frame for the cancerous tissue to form and increase the probability that it will occur so you can use a smaller test population.

As far as the breathtakingly immature “criticism” that papers are published so that the writers can be famous – well, of course.  All of human endeavor is based on things like that.  But if medical research did not represent real progress, not “pretend” progress then we would still be back in the dark ages with life expectancies in the 40s.